Abstract
Oligotyping for HLA-DRB1, DQA1 and DQB1 specificities has been performed on PCR-amplified DNA from 55 Italian celiac children, living in Rome, and 50 blood donors. 52.6% of CD patients were DR3;DQA1*0501;DQB1*0201-positive versus 14% of controls (RR = 6.85) and 34.5% were DR5,7;DQA1*DQB1*0201-positive versus 2% of controls (RR = 25.86). 7 patients (12.7%) were negative for the DQA1*0501/B1*0201 dimer: 3 of them were DR4 (5.4%) and the others typed as DR1,5; 1,7; 5,7 and w6,7. No patient was negative for both DQA1*0501 and DQB1*0201 alleles.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Celiac Disease / genetics*
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Child
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Child, Preschool
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DNA Probes, HLA / genetics
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Genes, MHC Class II*
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HLA-DQ Antigens / genetics*
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HLA-DQ alpha-Chains
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HLA-DQ beta-Chains
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HLA-DR Antigens / genetics*
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HLA-DRB1 Chains
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Histocompatibility Antigens Class II / genetics*
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Humans
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Italy
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Polymerase Chain Reaction
Substances
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DNA Probes, HLA
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HLA-DQ Antigens
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HLA-DQ alpha-Chains
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HLA-DQ beta-Chains
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HLA-DQA1 antigen
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HLA-DQB1 antigen
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HLA-DR Antigens
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HLA-DRB1 Chains
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Histocompatibility Antigens Class II