Abstract
A new definition is presented for minor-groove width in double-helical B-DNA structures. This uses interstrand H4' ... H5' rather than P ... P distances. It is shown by examination of various oligonucleotide crystal structures that these H4' ... H5' distances are a sensitive measure of minor-groove drug and protein binding, since these hydrogen atoms are in direct non-bonded contact with such bound ligands.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Composition
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Base Sequence
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DNA / chemistry*
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DNA-Binding Proteins / chemistry*
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Diminazene / analogs & derivatives*
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Diminazene / chemistry
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Macromolecular Substances
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Molecular Sequence Data
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Nucleic Acid Conformation*
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Structure-Activity Relationship
Substances
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DNA-Binding Proteins
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Macromolecular Substances
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DNA
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diminazene aceturate
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Diminazene