Minor-groove width and accessibility in B-DNA drug and protein complexes

FEBS Lett. 1992 Feb 17;298(1):97-9. doi: 10.1016/0014-5793(92)80030-k.

Abstract

A new definition is presented for minor-groove width in double-helical B-DNA structures. This uses interstrand H4' ... H5' rather than P ... P distances. It is shown by examination of various oligonucleotide crystal structures that these H4' ... H5' distances are a sensitive measure of minor-groove drug and protein binding, since these hydrogen atoms are in direct non-bonded contact with such bound ligands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Composition
  • Base Sequence
  • DNA / chemistry*
  • DNA-Binding Proteins / chemistry*
  • Diminazene / analogs & derivatives*
  • Diminazene / chemistry
  • Macromolecular Substances
  • Molecular Sequence Data
  • Nucleic Acid Conformation*
  • Structure-Activity Relationship

Substances

  • DNA-Binding Proteins
  • Macromolecular Substances
  • DNA
  • diminazene aceturate
  • Diminazene