Effects of anti-triadin antibody on Ca2+ release from sarcoplasmic reticulum

FEBS Lett. 1992 Mar 24;299(1):57-9. doi: 10.1016/0014-5793(92)80100-u.


The monoclonal antibody, mAb GE 4.90, raised against triadin, a 95 kDa protein of sarcoplasmic reticulum (SR), inhibits the slow phase of Ca2+ release from SR following depolarization of the T-tubule moiety of the triad. The antibody has virtually no effect on the fast phase of depolarization-induced Ca2+ release nor on caffeine-induced Ca2+ release. Since the slow phase of depolarization-induced Ca2+ release is also inhibited by dihydropyridines (DHP), these results suggest that triadin may be involved in the functional coupling between the DHP receptor and the SR Ca2+ channel.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Calcium / metabolism*
  • Carrier Proteins*
  • Kinetics
  • Muscle Proteins / antagonists & inhibitors
  • Muscle Proteins / metabolism*
  • Rabbits
  • Sarcoplasmic Reticulum / metabolism*


  • Antibodies, Monoclonal
  • Carrier Proteins
  • Muscle Proteins
  • triadin
  • Calcium