Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body. Effects of carbon monoxide

FEBS Lett. 1992 Mar 16;299(3):251-4. doi: 10.1016/0014-5793(92)80126-2.


K+ currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO2 in the bathing solution. Bath application of a hypoxic TTX-containing solution revealed that inhibition of K+ current by low pO2 proceeds faster than TTX inhibition of Na+ currents, the apparent t1/2 being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K+ currents by approx. 70%.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Monoxide / metabolism
  • Carotid Body / physiology*
  • Cells, Cultured
  • Hypoxia
  • Membrane Potentials / physiology*
  • Potassium / metabolism*
  • Rabbits
  • Sodium / metabolism


  • Carbon Monoxide
  • Sodium
  • Potassium