Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico

Am J Clin Nutr. 2004 Oct;80(4):855-61. doi: 10.1093/ajcn/80.4.855.


Background: An increased incidence of coronary artery disease (CAD) is prevalent in northern Mexico. Effects of specific dietary components on risk factors for CAD have not been evaluated in children.

Objective: The purpose was to evaluate the effects of dietary cholesterol provided by whole eggs on the lipoprotein profile, LDL size, and phenotype in children from this region.

Design: Children (29 girls and 25 boys aged 8-12 y) were randomly assigned to either 2 eggs/d (EGG period; 518 additional mg cholesterol) or the equivalent amount of egg whites (SUB period; 0 additional mg cholesterol) for 30 d. After a 3-wk washout period, the children were assigned to the alternate treatment.

Results: Subjects were classified as hyporesponders (no increase or </=0.05 mmol/L increase in plasma cholesterol for 100 mg additional cholesterol) or hyperresponders (>/=0.06 mmol/L increase). During the EGG period, the hyperresponders (n = 18) had an elevation in both LDL cholesterol (from 1.54 +/- 0.38 to 1.93 +/- 0.36 mmol/L) and HDL cholesterol (from 1.23 +/- 0.26 to 1.35 +/- 0.29 mmol/L) with no changes in LDL:HDL. In contrast, hyporesponders (n = 36) had no significant alterations in plasma LDL or HDL cholesterol. All subjects had an increase in LDL peak diameter during the EGG period (P < 0.01) and a decrease (P < 0.01) in the smaller LDL subfractions. In addition, 5 of the children having LDL phenotype B (15%) shifted from this high-risk pattern to pattern A after the EGG treatment.

Conclusions: Intake of 2 eggs/d results in the maintenance of LDL:HDL and in the generation of a less atherogenic LDL in this population of Mexican children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Biomarkers / blood
  • Child
  • Cholesterol / blood*
  • Cholesterol / metabolism
  • Cholesterol, Dietary / administration & dosage*
  • Cholesterol, Dietary / metabolism*
  • Cholesterol, HDL / blood
  • Cholesterol, HDL / metabolism
  • Cholesterol, LDL / blood
  • Cholesterol, LDL / chemistry
  • Cholesterol, LDL / metabolism
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / epidemiology
  • Coronary Artery Disease / metabolism
  • Cross-Over Studies
  • Eggs
  • Female
  • Humans
  • Male
  • Mexico / epidemiology
  • Particle Size
  • Phenotype
  • Risk Factors


  • Biomarkers
  • Cholesterol, Dietary
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Cholesterol