Exploring the post-transcriptional RNA world with DNA microarrays

Trends Biotechnol. 2004 Oct;22(10):498-500. doi: 10.1016/j.tibtech.2004.08.006.

Abstract

Genomic approaches are valuable for understanding the complex layer of gene regulation that involves the control of RNA processing, localization and stability. Recent work provides a prime example of the power of unbiased microarray-based methods to discover unexpected functions for proteins in the RNA world. The challenges ahead relate to extending such approaches to larger genomes and to integrating this type of information with that generated by standard expression profiling.

Publication types

  • Review

MeSH terms

  • Autoantigens
  • Gene Expression Profiling*
  • Gene Expression Regulation
  • Oligonucleotide Array Sequence Analysis / methods
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / metabolism
  • Ribonucleoproteins / metabolism

Substances

  • Autoantigens
  • RNA, Messenger
  • Ribonucleoproteins
  • SS-B antigen