Noc-king out exocrine and endocrine secretion

Trends Cell Biol. 2004 Oct;14(10):525-8. doi: 10.1016/j.tcb.2004.08.001.


The Rab GTPase effector Noc2 was brought into the limelight by a recent publication that demonstrated its requirements at different stages of regulated exocytosis. Noc2 knockout resulted in distinct abnormalities in endocrine and exocrine cells, ranging from the accumulation of secretory granules of increased size to impairments in the regulated release of their secretory products. Explanations for these defects are beginning to emerge and they promise to reveal some of the most jealously kept secrets of regulated exocytosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Endocrine Glands / metabolism*
  • Exocrine Glands / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Proteins / genetics*
  • Proteins / physiology


  • Adaptor Proteins, Signal Transducing
  • Intracellular Signaling Peptides and Proteins
  • Proteins
  • Rph3al protein, mouse