Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection

Fabien Zoulim

doi:10.1016/j.antiviral.2004.07.003

Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection

Antiviral Res. 2004 Oct;64(1):1-15. doi: 10.1016/j.antiviral.2004.07.003.

Author

Fabien Zoulim¹

Affiliation

¹ INSERM Unit 271, Insitut Universitaire de France, 151 Cours Albert Thomas, 69003 Lyon, France. zoulim@lyon.inserm.fr

PMID: 15451174
DOI: 10.1016/j.antiviral.2004.07.003

Abstract

Chronic Hepatitis B virus (HBV) infections remain a major problem public health problem worldwide, as well as a therapeutic challenge for clinicians. This review focuses on the main viral and host determinants involved in HBV persistence in infected cells. The mechanism of HBV resistance to nucleoside analogs are described as well as the concept for multiple drug therapy and combination with immunostimulatory approaches.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Antiviral Agents / therapeutic use*
Drug Resistance, Viral
Hepatitis B virus / drug effects
Hepatitis B virus / isolation & purification
Hepatitis B virus / physiology
Hepatitis B, Chronic / drug therapy*
Hepatitis B, Chronic / virology*
Humans
Nucleosides / pharmacology
Nucleotides / pharmacology
Phenotype
Virus Replication / drug effects

Substances

Antiviral Agents
Nucleosides
Nucleotides