Mechanism of viral persistence and resistance to nucleoside and nucleotide analogs in chronic hepatitis B virus infection

Antiviral Res. 2004 Oct;64(1):1-15. doi: 10.1016/j.antiviral.2004.07.003.


Chronic Hepatitis B virus (HBV) infections remain a major problem public health problem worldwide, as well as a therapeutic challenge for clinicians. This review focuses on the main viral and host determinants involved in HBV persistence in infected cells. The mechanism of HBV resistance to nucleoside analogs are described as well as the concept for multiple drug therapy and combination with immunostimulatory approaches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Drug Resistance, Viral
  • Hepatitis B virus / drug effects
  • Hepatitis B virus / isolation & purification
  • Hepatitis B virus / physiology
  • Hepatitis B, Chronic / drug therapy*
  • Hepatitis B, Chronic / virology*
  • Humans
  • Nucleosides / pharmacology
  • Nucleotides / pharmacology
  • Phenotype
  • Virus Replication / drug effects


  • Antiviral Agents
  • Nucleosides
  • Nucleotides