Abstract
Xanthones, 1,3-dihydroxy-5-methoxyxanthone-4-sulfonate and 1,3-dihydroxy-5-O-beta-D-glycopyranosylxanthone-4-sulfonate, together with nine known compounds were obtained from H. sampsonii. This is the first report of sulfonated xanthonoids. Furthermore, compounds 1 and 2 exhibited significant cytotoxicity against the P388 cancer cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Death / drug effects
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Cell Line, Tumor
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Hypericum / chemistry*
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Monosaccharides / chemistry*
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Monosaccharides / isolation & purification
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Monosaccharides / toxicity
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Xanthones / chemistry*
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Xanthones / isolation & purification
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Xanthones / toxicity
Substances
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1,3-dihydroxy-5-O-beta-D-glycopyranosylxanthone-4-sulfonate
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1,3-dihydroxy-5-methoxyxanthone-4-sulfonate
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Monosaccharides
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Xanthones