Sulfonated xanthones from Hypericum sampsonii

Phytochemistry. 2004 Sep;65(18):2595-8. doi: 10.1016/j.phytochem.2004.08.014.

Abstract

Xanthones, 1,3-dihydroxy-5-methoxyxanthone-4-sulfonate and 1,3-dihydroxy-5-O-beta-D-glycopyranosylxanthone-4-sulfonate, together with nine known compounds were obtained from H. sampsonii. This is the first report of sulfonated xanthonoids. Furthermore, compounds 1 and 2 exhibited significant cytotoxicity against the P388 cancer cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Death / drug effects
  • Cell Line, Tumor
  • Hypericum / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Monosaccharides / chemistry*
  • Monosaccharides / isolation & purification
  • Monosaccharides / toxicity
  • Xanthones / chemistry*
  • Xanthones / isolation & purification
  • Xanthones / toxicity

Substances

  • 1,3-dihydroxy-5-O-beta-D-glycopyranosylxanthone-4-sulfonate
  • 1,3-dihydroxy-5-methoxyxanthone-4-sulfonate
  • Monosaccharides
  • Xanthones