Short-term variations in bone remodeling markers of an oral contraception formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol: observational study in young postadolescent women

Contraception. 2004 Oct;70(4):293-8. doi: 10.1016/j.contraception.2004.04.004.


The clinical study of treated subjects and nontreated controls was made in healthy eumenorrheic young postadolescent women volunteers in the Department of Obstetrics and Gynaecology at Cagliari University, to investigate whether an oral contraceptive (OC) containing drospirenone (3 mg) plus ethinyl estradiol (30 microg) (DRSP+EE) can affect bone metabolism. Control group (n = 26) and OC group (n = 28) women did not differ in age, body mass index, waist-to-hip ratio and main outcome measures [urinary levels of deoxypyridinoline and pyridinoline, serum levels of osteocalcin, bone specific alkaline phosphatase (bSAP), total testosterone (total-T), sex hormone-binding globulin (SHBG), progesterone and bone mineral density (BMD) at the heel]. The control group was studied at the luteal phase (LP) during both the first and the sixth menstrual cycle; the OC group was studied during the first cycle at the LP, and on days 16-18 of the sixth cycle of DRSP+EE treatment. At the sixth cycle, in the control group, the main outcome measures did not change compared to baseline. In the OC group, deoxypyridinoline, pyridinoline, osteocalcin, bSAP, total-T and progesterone levels were reduced, whereas SHBG levels were increased. The BMD was unchanged compared to baseline. The results suggest that 6-month DRSP+EE treatment decreases bone turnover.

MeSH terms

  • Adult
  • Alkaline Phosphatase / blood
  • Amino Acids / urine
  • Androstenes / administration & dosage
  • Androstenes / adverse effects*
  • Biomarkers / analysis*
  • Body Mass Index
  • Bone Density
  • Bone Remodeling / drug effects*
  • Contraceptives, Oral / administration & dosage
  • Contraceptives, Oral / adverse effects*
  • Creatinine / urine
  • Ethinyl Estradiol / administration & dosage
  • Ethinyl Estradiol / adverse effects*
  • Female
  • Humans
  • Osteocalcin / blood
  • Progesterone / blood
  • Sex Hormone-Binding Globulin / analysis
  • Testosterone / blood
  • Waist-Hip Ratio


  • Amino Acids
  • Androstenes
  • Biomarkers
  • Contraceptives, Oral
  • Sex Hormone-Binding Globulin
  • Osteocalcin
  • Testosterone
  • Ethinyl Estradiol
  • Progesterone
  • pyridinoline
  • deoxypyridinoline
  • Creatinine
  • Alkaline Phosphatase
  • drospirenone