Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2004 Sep 28;63(6):1079-80.
doi: 10.1212/01.wnl.0000138572.82125.f5.

The Bioavailability of IV Methylprednisolone and Oral Prednisone in Multiple Sclerosis

Affiliations
Clinical Trial

The Bioavailability of IV Methylprednisolone and Oral Prednisone in Multiple Sclerosis

S A Morrow et al. Neurology. .

Abstract

Oral prednisone (1)might be a convenient, inexpensive alternative to IV methylprednisolone (IVMP) if the bioequivalent dose was known. We compared the total amount of steroid absorbed after 1250 mg oral prednisone vs 1 gram IVMP in 16 patients with multiple sclerosis (MS). At 24 hours, the mean area under the concentration-time curve (AUC), the main component of bioavailability, did not differ between groups (p = 0.122). This suggests that the amount of absorbed corticosteroid is similar after either steroid at these doses.

Comment in

Similar articles

See all similar articles

Cited by 18 articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback