Ectoin: an effective natural substance to prevent UVA-induced premature photoaging

Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):232-7. doi: 10.1159/000080216.


With the help of a new 'UVA stress model', it was shown that Ectoin protects the skin from the effects of UVA-induced cell damage in a number of different ways. Using cell cultures, high-performance thin-layer chromatography, gel electrophoresis mobility shift assays, reverse transcriptase polymerase chain reaction, ion exchange chromatography and UV spectroscopy, it was demonstrated that the UVA-induced second messenger release, transcription factor AP-2 activation, intercellular adhesion molecule-1 expression and mitochondrial DNA mutation could be prevented. The results obtained clearly demonstrate that Ectoin counteracts the effects of UVA-induced and accelerated skin aging at different cell levels.

MeSH terms

  • Aging, Premature / drug therapy
  • Amino Acids, Diamino / pharmacology*
  • Amino Acids, Diamino / therapeutic use
  • Biological Factors / pharmacology
  • Biological Factors / therapeutic use
  • Cells, Cultured
  • Humans
  • Keratinocytes / drug effects
  • Keratinocytes / physiology
  • Skin Aging / drug effects*
  • Skin Aging / radiation effects*
  • Ultraviolet Rays / adverse effects*


  • Amino Acids, Diamino
  • Biological Factors
  • ectoine