Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people

Bull Exp Biol Med. 2004 Apr;137(4):389-91. doi: 10.1023/b:bebm.0000035139.31138.bf.


Circadian rhythm of plasma melatonin concentrations in healthy elderly subjects was studied before and after a course treatment with Epithalamin (peptide preparation from the pineal gland). Epithalamin modulated the melatonin-producing function of the pineal gland. During the dark period plasma melatonin concentration increased in subjects with initially lowered activity of the pineal gland, while in subjects with normal epiphyseal function plasma melatonin concentration tended to decrease.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Animals
  • Circadian Rhythm / drug effects*
  • Female
  • Humans
  • Male
  • Melatonin / blood*
  • Peptides / pharmacology*
  • Photoperiod
  • Pineal Gland / drug effects
  • Pineal Gland / metabolism*
  • Seasons


  • Peptides
  • epithalamin
  • Melatonin