Immunotherapy for malignant gliomas: emphasis on strategies of active specific immunotherapy using autologous dendritic cells

Childs Nerv Syst. 2005 Jan;21(1):7-18. doi: 10.1007/s00381-004-0994-3. Epub 2004 Sep 28.


Review: In this review, we discuss immunotherapy for malignant gliomas.

Emphasis: The emphasis is on the novel strategy of active specific immunotherapy using dendritic cells as antigen-presenting cells, especially its theoretical concepts and advantages, specific requirements, critical issues, pre-clinical and early clinical experience. Dendritic cell vaccination is situated in the diversity of other immunotherapeutical approaches.

Further discussion: Future directions, challenges, and drawbacks will be discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology
  • Cancer Vaccines / therapeutic use*
  • Central Nervous System Neoplasms / therapy*
  • Dendritic Cells / immunology
  • Dendritic Cells / transplantation*
  • Glioma / therapy*
  • Humans
  • Immunotherapy, Active*
  • Models, Biological


  • Antigens, Neoplasm
  • Cancer Vaccines