Cryoablation of benign breast tumors: evolution of technique and technology

Breast. 2004 Oct;13(5):397-407. doi: 10.1016/j.breast.2004.04.008.


We report on improvements in cryoprobe design and techniques of cryoablation as a minimally invasive alternative to open surgery for the treatment of benign breast tumors. In the study, which was conducted in 12 centers, 124 lesions in 102 patients were monitored for a period of 12 months after cryoablation. Two different treatment techniques were used: Double HI FREEZE and Tailored Freeze. In patients treated with the Tailored Freeze technique significantly better results were recorded 12 months after the procedure: the median reduction in tumor volume was 91%, 73% of all tumors treated were nonpalpable, 84% of lesions less than 2.5 cm in maximum diameter were nonpalpable, and none of the 31 mammograms performed yielded abnormal findings. Patient satisfaction was good to excellent in 92% of the patients. The safety profile of this technique was excellent; all complications were minor. Evolution of cryoablation freezing techniques, coupled with improvements in cryoprobe design, has resulted in significant improvements in both safety and effectiveness.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biopsy, Needle
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / surgery*
  • Cryosurgery / methods*
  • Female
  • Fibroadenoma / diagnosis
  • Fibroadenoma / surgery*
  • Humans
  • Mammography
  • Middle Aged
  • Treatment Outcome
  • Ultrasonography, Mammary