Toll-like Receptors in the Pathogenesis of Human Disease

Nat Immunol. 2004 Oct;5(10):975-9. doi: 10.1038/ni1116.

Abstract

Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / etiology
  • Asthma / etiology
  • Autoimmune Diseases / etiology
  • Bacterial Infections / etiology
  • Humans
  • I-kappa B Kinase
  • Immune Tolerance
  • Membrane Glycoproteins / physiology*
  • Protein-Serine-Threonine Kinases / physiology
  • Receptors, Cell Surface / physiology*
  • Sepsis / etiology
  • Toll-Like Receptors

Substances

  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors
  • Protein-Serine-Threonine Kinases
  • CHUK protein, human
  • I-kappa B Kinase
  • IKBKB protein, human
  • IKBKE protein, human