Toll-like Receptor Control of the Adaptive Immune Responses

Nat Immunol. 2004 Oct;5(10):987-95. doi: 10.1038/ni1112.

Abstract

Recognition of microbial infection and initiation of host defense responses is controlled by multiple mechanisms. Toll-like receptors (TLRs) have recently emerged as a key component of the innate immune system that detect microbial infection and trigger antimicrobial host defense responses. TLRs activate multiple steps in the inflammatory reactions that help to eliminate the invading pathogens and coordinate systemic defenses. In addition, TLRs control multiple dendritic cell functions and activate signals that are critically involved in the initiation of adaptive immune responses. Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Antibody Formation
  • B-Lymphocytes / immunology
  • Cell Movement
  • Dendritic Cells / physiology
  • Humans
  • Immunity, Innate*
  • Interferon Type I / physiology
  • Lymphocyte Activation
  • Membrane Glycoproteins / physiology*
  • Receptors, Cell Surface / physiology*
  • Stromal Cells / physiology
  • T-Lymphocytes / immunology
  • Toll-Like Receptors

Substances

  • Interferon Type I
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors