Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people

Bull Exp Biol Med. 2004 May;137(5):507-9. doi: 10.1023/b:bebm.0000038165.09563.b5.


The effect of epithalamin on circadian rhythms of thymic serum factor titers and melatonin concentrations in the blood of elderly people was studied. Course treatment with epithalamin modulated the rhythm of the thymic endocrine function. The increase in the titer of thymic serum factor at night coincided with the increase in blood melatonin concentration and shift of its acrophase to 3.00, which was characteristic of young people. In elderly people with preserved nocturnal peak of the thymic serum factor titer before therapy the nocturnal (3.00) concentration of melatonin was high and did not change after drug therapy. The correlation between melatonin concentration and titer of thymic serum factor increased after epithalamin treatment.

MeSH terms

  • Aged
  • Circadian Rhythm / drug effects*
  • Female
  • Humans
  • Male
  • Melatonin / blood*
  • Melatonin / metabolism
  • Middle Aged
  • Peptides / pharmacology*
  • Pineal Gland / drug effects*
  • Pineal Gland / metabolism
  • Thymic Factor, Circulating / analysis
  • Thymic Factor, Circulating / metabolism
  • Thymus Gland / drug effects*
  • Thymus Gland / metabolism


  • Peptides
  • epithalamin
  • Thymic Factor, Circulating
  • Melatonin