Identification of a familial cluster of pulmonary Mycobacterium bovis disease

Int J Tuberc Lung Dis. 2004 Sep;8(9):1142-6.


Setting: Local public health department.

Design: Retrospective review of a cluster of three pulmonary Mycobacterium bovis cases occurring in a family, with genotyping of M. bovis strains isolated from the family members.

Results: The genotypes of the M. bovis isolates were identical, as determined by three different methods: IS6110 restriction fragment length polymorphism, spoligoytping and mycobacterial interspersed repetitive units-variable number tandem repeat analyses.

Conclusion: The identification of three acid-fast bacilli (AFB) smear-positive pulmonary M. bovis cases, presenting in a single family and caused by an identical strain, suggests that person-to-person transmission of this organism may have occurred, although infection of one or more family members through ingestion of a contaminated dairy product could not be excluded.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Dairy Products
  • Family Health
  • Female
  • Food Contamination
  • Genotype
  • Humans
  • Male
  • Molecular Epidemiology
  • Mycobacterium bovis / genetics*
  • Mycobacterium bovis / pathogenicity*
  • Polymorphism, Restriction Fragment Length
  • Retrospective Studies
  • Tuberculosis, Pulmonary / genetics*
  • Tuberculosis, Pulmonary / microbiology*