Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep 29;4:8.
doi: 10.1186/1471-2318-4-8.

Moderate Exercise May Attenuate Some Aspects of Immunosenescence

Affiliations
Free PMC article

Moderate Exercise May Attenuate Some Aspects of Immunosenescence

Nadzieja Drela et al. BMC Geriatr. .
Free PMC article

Abstract

Background: Immunosenescence is related to the deterioration of many immune functions, which may be manifested in increased susceptibility to infection, cancer, and autoimmunity. Lifestyle factors, such as diet or physical activity, may influence the senescence of the immune system. It is widely accepted that moderate physical activity may cause beneficial effects for physical and psychological health as well as for the immune system activity in aged people.

Methods: Thirty elderly women aged 62 to 86 were subjected to a two-years authorized physical activity program. Peripheral blood lymphocytes distribution and the production of cytokines involved in the immune response development and regulation (IL-2, IL-4 and IFN-gamma) were investigated. The same parameters were evaluated in two control groups of women: a sedentary group of 12 elderly women selected for the second round of the physical activity program and in a group of 20 sedentary young women. Flow cytometry methods were used for the examination of surface markers on peripheral blood lymphocytes and intracellular cytokines expression.

Results: The distribution of the main lymphocytes subpopulations in the peripheral blood of elderly women did not show changes after long-term moderate physical training. The percentage of lymphocytes expressing intracellular IL-2 was higher in the group of women attending 2-years physical activity program than in the control group of elderly sedentary women, and it was similar to the value estimated in the group of young sedentary women. There was no difference in the intracellular expression of IL-4 and IFN-gamma between the active and elderly sedentary women.

Conclusions: Our results suggest that moderate, long-term physical activity in elderly women may increase the production of IL-2, an important regulator of the immune response. This may help ameliorate immunosenescence in these women.

Figures

Figure 1
Figure 1
Distribution of peripheral blood lymphocyte subpopulations. Ctrl A – elderly women starting with the physical activity program. After the program (up to 70) – up to 70 years old women after the physical activity program. After the program (over 70) – over 70 years old women after the physical activity program
Figure 2
Figure 2
Intracellular cytokines expression in activated peripheral blood lymphocytes. Ctrl A – elderly women starting with the physical activity program. After the program – elderly exercised women. Ctrl B – young, sedentary women. Statistically significant data from Ctrl A are denoted by black stars. Statistically significant data from Ctrl B are denoted by black triangles.
Figure 3
Figure 3
Intracellular cytokines expression in activated peripheral blood lymphocytes. A/ Ctrl A – elderly women starting with the physical activity program, B/ elderly exercised women, C/ Ctrl B – sedentary, young women. FL2 – lymphocytes positive for intracellular cytokines. Lymphocytes with intracellular cytokine expression are situated in the upper left (UL) part of the quadrant.

Similar articles

See all similar articles

Cited by 16 articles

See all "Cited by" articles

References

    1. Hannet I, Erkeller-Yuksel F, Lydyard P, Deneys V, De Bruyere M. Developmental and maturational changes in human blood lymphocyte subpopulations. Immunol Today. 1992;13:215–218. doi: 10.1016/0167-5699(92)90157-3. - DOI - PubMed
    1. Paganelli R, Quinti I, Fagiolo U, Cossarizza A, Ortolani G, Guerra E, Sansoni P, Pucillo LP, Scala E, Cozzi E. Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy age population. Clin Exp Immunol. 1992;90:351–354. - PMC - PubMed
    1. Globerson A, Effros RB. Ageing of lymphocytes and lymphocytes in the aged. Immunol Today. 2000;21:515–521. doi: 10.1016/S0167-5699(00)01714-X. - DOI - PubMed
    1. Colonna-Romano G, Bulati M, Aquino A, Scialabba G, Candore G, Lio D, Motta M, Malaguarnera M, Caruso C. B cells in the aged: CD27, CD5 and CD40 expression. Mech Ageing Dev. 2003;124:389–393. doi: 10.1016/S0047-6374(03)00013-7. - DOI - PubMed
    1. Globerson A. T lymphocytes and aging. Int Arch Allergy Immunol. 1995;107:491–497. - PubMed

LinkOut - more resources

Feedback