Causative and preventive action of calcium in cataracto-genesis

Acta Pharmacol Sin. 2004 Oct;25(10):1250-6.


Calcium and Ca-dependent enzymes play specific role in the development of human cataracts. Entry of Ca2+ into the lens epithelial cells (LEC) is highly regulated by quantum of receptors. The Ca2+ level controls homeostasis and growth of entire lens. Intracellular overload of Ca2+ in the LEC trigger a series of events such as activation of Ca-dependent enzymes, irreversible breakdown of important structural proteins and cell death. Proper maintenance of Ca2+ levels by regulating activity of Ca-pumps and Ca-channels and inhibition of Ca-dependent enzymes can help in prevention of cataract. Induction of cell death in the LEC by increase in the intracellular Ca2+ may be utilized for the prevention of posterior capsular opacification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channel Blockers / pharmacology
  • Calcium Signaling / physiology
  • Cataract / etiology*
  • Cataract / metabolism
  • Cataract / prevention & control
  • Cell Death
  • Epithelial Cells / metabolism
  • Humans
  • Lens, Crystalline / metabolism*
  • Lens, Crystalline / pathology
  • Verapamil / pharmacology


  • Calcium Channel Blockers
  • Verapamil
  • Calcium