An investigation of impulsivity in children with early-treated congenital hypothyroidism

Dev Neuropsychol. 2004;26(2):595-610. doi: 10.1207/s15326942dn2602_4.

Abstract

The main feature of congenital hypothyroidism (CH) is a total or partial absence of thyroid hormone, caused by a developmental disorder of the thyroid gland. Introduction of neonatal thyroid screening allows early treatment with replacement hormone. As a result the prognosis of CH has greatly improved but neuropsychological problems do still occur. Claims that early-treated CH is associated with impulsivity were tested with a memory search task comprising 2 response probability conditions: a baseline condition in which "yes" and "no" responses were equally probable and a response bias condition in which the probability of a "no" response was raised to 70%. Impulsivity was defined as the ability to stop and change a response set and was assessed from the amount of inaccurate "no" responses made. Comparisons were made between 47 children with early-treated CH and 35 controls at the age of 7.5 years. Children with early-treated CH were notably slow and variable in their overall task performance but, most important, did not show signs of poor impulse control. Suggested short-term memory problems in these children could not be confirmed. Performance could not be attributed to early disease-related factors or lowered intelligence.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Case-Control Studies
  • Child
  • Cohort Studies
  • Congenital Hypothyroidism
  • Female
  • Hormone Replacement Therapy*
  • Humans
  • Hypothyroidism / drug therapy
  • Hypothyroidism / psychology*
  • Impulsive Behavior / drug therapy*
  • Infant, Newborn
  • Intelligence / drug effects*
  • Intelligence / physiology
  • Intelligence Tests
  • Longitudinal Studies
  • Male
  • Neonatal Screening
  • Neuropsychological Tests / statistics & numerical data
  • Reaction Time / physiology