Predictors of quality of life among long-term survivors of gestational trophoblastic disease

J Reprod Med. 2004 Aug;49(8):589-94.


Objective: To identify predictors of quality of life (QOL) among women diagnosed with gestational trophoblastic tumor (GTT) 5-10 years earlier.

Study design: Utilizing a cross-sectional, descriptive design, 111 survivors completed a comprehensive QOL interview.

Results: Univariate analyses revealed that numerous psychosocial variables correlated highly with overall QOL. However, multivariate analysis indicated that the significant predictors of long-term QOL were cancer-specific distress, social support, spiritual well-being, reproductive concerns, gynecologic pain and sexual functioning. These 6 variables accounted for 77% of the variance in the overall QOL score. Post hoc analyses demonstrated that each of the predictors had unique effects on the QOL score.

Conclusion: The variables identified in this model can guide future research and clinical care to reduce short- and long-term burdens associated with GTT.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Cross-Sectional Studies
  • Female
  • Gestational Trophoblastic Disease / pathology*
  • Health Surveys
  • Humans
  • Middle Aged
  • Multivariate Analysis
  • Pain
  • Prognosis
  • Quality of Life*
  • Sexuality
  • Social Support
  • Spirituality
  • Stress, Psychological
  • Survival Analysis