Adherin: Key to the Cohesin Ring and Cornelia De Lange Syndrome

Curr Biol. 2004 Oct 5;14(19):R834-6. doi: 10.1016/j.cub.2004.09.035.

Abstract

Adherin facilitates sister chromatid cohesion, DNA repair and binding of the cohesin complex to chromosomes. New studies indicate that adherin activity is coordinated with DNA replication and chromosome segregation, and that its dosage is critical for gene expression and human development.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Cycle Proteins / physiology*
  • Chromatids / metabolism
  • Chromosome Segregation / physiology*
  • Chromosomes / metabolism
  • DNA Replication / physiology*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • DNA-Binding Proteins / physiology*
  • De Lange Syndrome / genetics*
  • Gene Expression / physiology
  • Humans
  • Models, Biological*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins