Checking on DNA damage in S phase

Nat Rev Mol Cell Biol. 2004 Oct;5(10):792-804. doi: 10.1038/nrm1493.

Abstract

The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism*
  • Cell Line
  • Checkpoint Kinase 1
  • Checkpoint Kinase 2
  • DNA Damage*
  • DNA-Binding Proteins
  • Enzyme Activation
  • Genes, cdc
  • Humans
  • Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism
  • S Phase* / physiology
  • Signal Transduction / physiology
  • Time Factors
  • Tumor Suppressor Proteins
  • cdc25 Phosphatases / metabolism

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • Protein Kinases
  • Checkpoint Kinase 2
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK2 protein, human
  • Checkpoint Kinase 1
  • Protein-Serine-Threonine Kinases
  • CDC25A protein, human
  • cdc25 Phosphatases