Connecting proliferation and apoptosis in development and disease

Nat Rev Mol Cell Biol. 2004 Oct;5(10):805-15. doi: 10.1038/nrm1491.

Abstract

Cells grow and divide rapidly during embryonic and postnatal development. Net tissue growth reflects the balance between the addition of new cells and the elimination of existing cells by programmed cell death. Cells compete for growth and survival factors to ensure an appropriate balance between the addition and elimination of cells. Elaborate mechanisms ensure that cells do not evade these constraints, and thereby prevent uncontrolled proliferation.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Cell Cycle / physiology
  • Cell Division / physiology*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism
  • Embryo, Mammalian / anatomy & histology
  • Embryo, Mammalian / physiology
  • Embryo, Nonmammalian
  • Genes, p16
  • Nuclear Proteins / metabolism
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-mdm2
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Drosophila Proteins
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-myc
  • Tumor Suppressor Protein p53
  • Proto-Oncogene Proteins c-mdm2
  • Protein-Serine-Threonine Kinases
  • Slik protein, Drosophila