Integrin signalling during tumour progression

Nat Rev Mol Cell Biol. 2004 Oct;5(10):816-26. doi: 10.1038/nrm1490.


During progression from tumour growth to metastasis, specific integrin signals enable cancer cells to detach from neighbouring cells, re-orientate their polarity during migration, and survive and proliferate in foreign microenvironments. There is increasing evidence that certain integrins associate with receptor tyrosine kinases (RTKs) to activate signalling pathways that are necessary for tumour invasion and metastasis. The effect of these integrins might be especially important in cancer cells that have activating mutations, or amplifications, of the genes that encode these RTKs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Movement / physiology
  • Cell Survival
  • Extracellular Matrix / metabolism
  • Integrins / genetics
  • Integrins / metabolism*
  • Models, Biological
  • Neoplasm Metastasis*
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Neovascularization, Pathologic
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Signal Transduction / physiology*


  • Integrins
  • Receptor Protein-Tyrosine Kinases