Molecular mechanisms of translational control

Nat Rev Mol Cell Biol. 2004 Oct;5(10):827-35. doi: 10.1038/nrm1488.


Translational control is widely used to regulate gene expression. This mode of regulation is especially relevant in situations where transcription is silent or when local control over protein accumulation is required. Although many examples of translational regulation have been described, only a few are beginning to be mechanistically understood. Instead of providing a comprehensive account of the examples that are known at present, we discuss instructive cases that serve as paradigms for different modes of translational control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eukaryotic Initiation Factor-2 / metabolism
  • Eukaryotic Initiation Factor-4E / metabolism
  • Gene Expression Regulation*
  • Macromolecular Substances
  • MicroRNAs / metabolism
  • Models, Genetic
  • Nucleic Acid Conformation
  • Protein Biosynthesis*
  • RNA, Messenger / chemistry
  • RNA, Messenger / metabolism
  • Ribosomes / metabolism


  • Eukaryotic Initiation Factor-2
  • Eukaryotic Initiation Factor-4E
  • Macromolecular Substances
  • MicroRNAs
  • RNA, Messenger