IDO Expression by Dendritic Cells: Tolerance and Tryptophan Catabolism

Nat Rev Immunol. 2004 Oct;4(10):762-74. doi: 10.1038/nri1457.

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Dendritic Cells / metabolism*
  • Humans
  • Immune Tolerance*
  • Immunosuppression
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Models, Immunological*
  • Tryptophan / metabolism*
  • Tryptophan Oxygenase / biosynthesis*

Substances

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Tryptophan
  • Tryptophan Oxygenase