A protective role for innate immunity in systemic lupus erythematosus

Nat Rev Immunol. 2004 Oct;4(10):825-31. doi: 10.1038/nri1456.


Clinical and genetic studies in humans and animal models indicate a crucial protective role for the complement system in systemic lupus erythematosus (SLE). This presents a paradox because the complement system is considered to be an important mediator of the inflammation that is observed in patients with SLE. One current view is that complement provides protection by facilitating the rapid removal of apoptotic debris to circumvent an autoimmune response. In this Opinion article, I discuss an alternative model in which complement - together with other components of the innate immune system - participates in the 'presentation' of SLE-inducing self-antigens to developing B cells. In this way, the complement system and innate immunity protect against responses to SLE (self) antigens by enhancing the elimination of self-reactive lymphocytes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Autoantigens / immunology
  • Autoimmunity / physiology*
  • B-Lymphocytes / immunology*
  • Clonal Deletion / immunology
  • Complement System Proteins / immunology*
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Humans
  • Immunity, Innate*
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • Mice
  • Models, Immunological


  • Autoantigens
  • Complement System Proteins