Synthesis of new diselenide compounds as anti-inflammatory agents

Arch Pharm Res. 2004 Aug;27(8):816-9. doi: 10.1007/BF02980171.

Abstract

Many diselenide compounds are used as antioxidants, enzyme inhibitors and cytokine inducers. Three new diselenide compounds, bis-(2-hydroxyphenyl) diselenide, bis-(3-hydroxyphenyl) diselenide and bis-(4-hydroxyphenyl) diselenide were designed and synthesized as anti-inflammatory agent. All of them were found to have strong in vitro activity in anti-inflammatory assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cell Line
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Cyclooxygenase 2
  • Dose-Response Relationship, Drug
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism
  • Mice
  • Nitric Oxide Synthase / antagonists & inhibitors
  • Nitric Oxide Synthase / metabolism
  • Nitric Oxide Synthase Type II
  • Organoselenium Compounds / chemical synthesis*
  • Organoselenium Compounds / pharmacology*
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Selenium / chemistry
  • Selenium / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Isoenzymes
  • Organoselenium Compounds
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • Selenium