Abstract
Many diselenide compounds are used as antioxidants, enzyme inhibitors and cytokine inducers. Three new diselenide compounds, bis-(2-hydroxyphenyl) diselenide, bis-(3-hydroxyphenyl) diselenide and bis-(4-hydroxyphenyl) diselenide were designed and synthesized as anti-inflammatory agent. All of them were found to have strong in vitro activity in anti-inflammatory assays.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cell Line
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Cell Survival / drug effects
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Cell Survival / physiology
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Cyclooxygenase 2
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Dose-Response Relationship, Drug
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / metabolism
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Mice
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Nitric Oxide Synthase / antagonists & inhibitors
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Nitric Oxide Synthase / metabolism
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Nitric Oxide Synthase Type II
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Organoselenium Compounds / chemical synthesis*
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Organoselenium Compounds / pharmacology*
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Prostaglandin-Endoperoxide Synthases / metabolism
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Selenium / chemistry
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Selenium / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Isoenzymes
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Organoselenium Compounds
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Nos2 protein, mouse
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Selenium