Abstract
Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 --> 6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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DNA-Binding Proteins / antagonists & inhibitors*
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DNA-Binding Proteins / metabolism
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Eleutherococcus*
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NFATC Transcription Factors
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Nuclear Proteins / antagonists & inhibitors*
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Nuclear Proteins / metabolism
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Roots
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / metabolism
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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3,11-dihydroxylup-20(29)-en-28-oic acid
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DNA-Binding Proteins
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NFATC Transcription Factors
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Nuclear Proteins
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Plant Extracts
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Transcription Factors
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Triterpenes