Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription

Arch Pharm Res. 2004 Aug;27(8):825-8. doi: 10.1007/BF02980173.

Abstract

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 --> 6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA-Binding Proteins / antagonists & inhibitors*
  • DNA-Binding Proteins / metabolism
  • Eleutherococcus*
  • NFATC Transcription Factors
  • Nuclear Proteins / antagonists & inhibitors*
  • Nuclear Proteins / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Roots
  • Transcription Factors / antagonists & inhibitors*
  • Transcription Factors / metabolism
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • 3,11-dihydroxylup-20(29)-en-28-oic acid
  • DNA-Binding Proteins
  • NFATC Transcription Factors
  • Nuclear Proteins
  • Plant Extracts
  • Transcription Factors
  • Triterpenes