Adaptive-optics ultrahigh-resolution optical coherence tomography

Opt Lett. 2004 Sep 15;29(18):2142-4. doi: 10.1364/ol.29.002142.


Merging of ultrahigh-resolution optical coherence tomography (UHR OCT) and adaptive optics (AO), resulting in high axial (3 microm) and improved transverse resolution (5-10 microm) is demonstrated for the first time to our knowledge in in vivo retinal imaging. A compact (300 mm x 300 mm) closed-loop AO system, based on a real-time Hartmann-Shack wave-front sensor operating at 30 Hz and a 37-actuator membrane deformable mirror, is interfaced to an UHR OCT system, based on a commercial OCT instrument, employing a compact Ti:sapphire laser with 130-nm bandwidth. Closed-loop correction of both ocular and system aberrations results in a residual uncorrected wave-front rms of 0.1 microm for a 3.68-mm pupil diameter. When this level of correction is achieved, OCT images are obtained under a static mirror configuration. By use of AO, an improvement of the transverse resolution of two to three times, compared with UHR OCT systems used so far, is obtained. A significant signal-to-noise ratio improvement of up to 9 dB in corrected compared with uncorrected OCT tomograms is also achieved.

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Equipment Design
  • Equipment Failure Analysis
  • Feedback
  • Humans
  • Ophthalmoscopes*
  • Ophthalmoscopy / methods
  • Retina / pathology*
  • Tomography, Optical Coherence / instrumentation*
  • Tomography, Optical Coherence / methods