Is secondary lymphoid-organ chemokine (SLC/CCL21) much more than a constitutive chemokine?

Allergy. 2004 Nov;59(11):1219-23. doi: 10.1111/j.1398-9995.2004.00531.x.


Chemokines are a superfamily of small cytokines with activities ranging from leukocyte traffick to hematopoiesis, angiogenesis, and tissue organogenesis. Secondary lymphoid-organ chemokine (SLC/CCL21) was originally reported as a chemokine constitutively expressed by stromal cells and high endothelial venules in secondary lymphoid tissues and endothelium of afferent lymphatics, directing CCR7+ cells. More recently, others and we have demonstrated that SLC/CCL21 is up-regulated in different skin inflammatory conditions. Thereafter, this molecule is much more than a constitutive chemokine, which could play a role in effector and regulatory immune functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chemokine CCL21
  • Chemokines
  • Chemokines, CC / immunology*
  • Chemotaxis, Leukocyte
  • Humans
  • Lymphoid Tissue / immunology*


  • CCL21 protein, human
  • Chemokine CCL21
  • Chemokines
  • Chemokines, CC