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Bioconductor: Open Software Development for Computational Biology and Bioinformatics


Bioconductor: Open Software Development for Computational Biology and Bioinformatics

Robert C Gentleman et al. Genome Biol.


The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary scientific research, and promoting the achievement of remote reproducibility of research results. We describe details of our aims and methods, identify current challenges, compare Bioconductor to other open bioinformatics projects, and provide working examples.


Figure 1
Figure 1
Limma analysis of the ALL data. The leftmost numbers are row indices, ID is the Affymetrix HGU95av2 accession number, M is the log ratio of expression, A is the log average expression, and B is the log odds of differential expression.
Figure 2
Figure 2
Heat map (produced by the Bioconductor function heatmap()) of the ALL leukemia data.
Figure 3
Figure 3
Hypergeometric analysis of molecular function enrichment of genes selected in the analysis described in Figure 1.

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