Hotspots of homologous recombination in the human genome: not all homologous sequences are equal

Genome Biol. 2004;5(10):242. doi: 10.1186/gb-2004-5-10-242. Epub 2004 Sep 28.


Homologous recombination between alleles or non-allelic paralogous sequences does not occur uniformly but is concentrated in 'hotspots' with high recombination rates. Recent studies of these hotspots show that they do not share common sequence motifs, but they do have other features in common.

Publication types

  • Review

MeSH terms

  • Animals
  • Genome, Human*
  • Humans
  • Recombination, Genetic / genetics*
  • Sequence Homology, Nucleic Acid*