Eicosanoids as immunomodulators of penetration by Schistosome cercariae

B Salafsky; A Fusco

doi:10.1016/0169-4758(87)90106-2

Eicosanoids as immunomodulators of penetration by Schistosome cercariae

Parasitol Today. 1987 Sep;3(9):279-81. doi: 10.1016/0169-4758(87)90106-2.

Authors

B Salafsky¹, A Fusco

Affiliation

¹ Department of Biomedical Sciences, University of Illinois, College of Medicine at Rockford, Rockford, IL 61107, USA.

PMID: 15462982
DOI: 10.1016/0169-4758(87)90106-2

Abstract

To infect a definitive host, schistosome cercorioe must identify and penetrate intact skin. This involves complex biochemical and morphological changes over a fairly brief time (48 hours), and possibly offers a potential point of intervention against infection. Attempts to define a vaccine against the invading organisms have so far been unsuccessful, but unravelling the complex biochemical interactions of schistosome penetration and transformation seems to suggest possible pharmacological or immunopharmacological interventions against these initial stages of infection.