Ciprofloxacin-induced renal insufficiency in cystic fibrosis

J Cyst Fibros. 2003 Sep;2(3):152-4. doi: 10.1016/S1569-1993(03)00059-6.


Acute renal insufficiency is known to occur in patients who are taking ciprofloxacin, particularly the elderly. We report two young patients with cystic fibrosis who presented with acute renal insufficiency after 2-3 weeks of oral ciprofloxacin therapy. The incidence of this adverse effect in children and young adults who have cystic fibrosis is unknown. Multiple mechanisms for ciprofloxacin-induced nephrotoxicity have been proposed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Adolescent
  • Adult
  • Anti-Infective Agents / adverse effects*
  • Anti-Infective Agents / therapeutic use
  • Blood Urea Nitrogen
  • Ciprofloxacin / adverse effects*
  • Ciprofloxacin / therapeutic use
  • Creatinine / blood
  • Cystic Fibrosis / drug therapy*
  • Female
  • Humans


  • Anti-Infective Agents
  • Ciprofloxacin
  • Creatinine