Neurotrophin action on a rapid timescale

Curr Opin Neurobiol. 2004 Oct;14(5):558-63. doi: 10.1016/j.conb.2004.08.014.


Mechanisms underlying the fast action of neurotrophins include intracellular Ca(2+) signaling, neuronal excitation, augmentation of synaptic excitation by modulation of N-methyl-d-aspartate receptor activity and control of synaptic inhibition through the regulation of the K(+)-Cl(-) cotransporter KCC2. The fastest action of brain-derived neurotrophic factor and neurotrophin-4/5 occurs within milliseconds, and involves activation of TrkB and the opening of the Na(+) channel Na(v)1.9. Through these rapid actions, neurotrophins shape neuronal activity, modulate synaptic transmission and produce instructive signals for the induction of long-term changes in the efficacy of synaptic transmission.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium Signaling / physiology
  • Central Nervous System / physiology*
  • Humans
  • Ion Channels / physiology
  • Nerve Growth Factors / physiology*
  • Reaction Time / physiology
  • Synapses / physiology*
  • Synaptic Membranes / physiology
  • Synaptic Transmission / physiology*
  • Time Factors


  • Ion Channels
  • Nerve Growth Factors