Treatment of idiopathic hemifacial spasm with botulinum toxin

Acta Neurol Scand. 1992 Jan;85(1):55-7. doi: 10.1111/j.1600-0404.1992.tb03995.x.


Twelve patients with idiopathic hemifacial spasm received treatment with botulinum toxin A over a period of 18 months. Of 76 treatments given, most (94.7%) led to successful relief of eyelid spasms and all treatments were successful for perioral and lower facial muscle spasms. An average dose of 9.3 units of toxin per session was given to produce a mean interval of relief of 10.8 weeks. Blepharoptosis was the only ocular side effect; it was mild, reversible and occurred in 2 patients. However, lower facial palsy was frequent (9 patients); it was mild to moderate in severity but only partially reversible in 8 patients. Dosage for lower facial muscles should therefore be reduced.

MeSH terms

  • Adult
  • Aged
  • Blepharospasm / therapy*
  • Botulinum Toxins / administration & dosage*
  • Facial Muscles / drug effects*
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neurologic Examination
  • Spasm / therapy*


  • Botulinum Toxins