Correlation between dopamine D(2) receptors in the ventral striatum and central processing of alcohol cues and craving

Am J Psychiatry. 2004 Oct;161(10):1783-9. doi: 10.1176/appi.ajp.161.10.1783.


Objective: Alcohol and other drugs of abuse stimulate dopamine release in the ventral striatum, which includes the nucleus accumbens, a core region of the brain reward system, and reinforce substance intake. Chronic alcohol intake is associated with down-regulation of central dopamine D(2) receptors, and delayed recovery of D(2) receptor sensitivity after detoxification is positively correlated with high risk for relapse. Prolonged D(2) receptor dysfunction in the ventral striatum may interfere with a dopamine-dependent error detection signal and bias the brain reward system toward excessive attribution of incentive salience to alcohol-associated stimuli.

Method: Multimodal imaging, with the radioligand [(18)F]desmethoxyfallypride and positron emission tomography as well as functional magnetic resonance imaging (fMRI), was used to compare 11 detoxified male alcoholics with 13 healthy men. The authors measured the association of D(2)-like dopamine receptors in the ventral striatum with alcohol craving and central processing of alcohol cues.

Results: Activation of the medial prefrontal cortex and striatum by alcohol-associated stimuli, relative to activation by neutral visual stimuli, was greater in the detoxified alcoholics than in the healthy men. The alcoholics displayed less availability of D(2)-like receptors in the ventral striatum, which was associated with alcohol craving severity and with greater cue-induced activation of the medial prefrontal cortex and anterior cingulate as assessed with fMRI.

Discussion: In alcoholics, dopaminergic dysfunction in the ventral striatum may attribute incentive salience to alcohol-associated stimuli, so that alcohol cues elicit craving and excessive activation of neural networks associated with attention and behavior control.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcohol Drinking / physiopathology
  • Alcohol Drinking / psychology*
  • Alcoholism / psychology*
  • Alcoholism / rehabilitation
  • Attention / drug effects
  • Attention / physiology
  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / drug effects*
  • Basal Ganglia / physiology*
  • Behavior, Addictive / diagnostic imaging
  • Behavior, Addictive / psychology*
  • Cues*
  • Ethanol / pharmacology*
  • Fluorine Radioisotopes
  • Gyrus Cinguli / diagnostic imaging
  • Gyrus Cinguli / drug effects
  • Gyrus Cinguli / physiology
  • Humans
  • Magnetic Resonance Imaging / statistics & numerical data
  • Male
  • Middle Aged
  • Neural Pathways / diagnostic imaging
  • Neural Pathways / drug effects
  • Neural Pathways / physiology
  • Nucleus Accumbens / diagnostic imaging
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / physiology
  • Prefrontal Cortex / diagnostic imaging
  • Prefrontal Cortex / drug effects
  • Prefrontal Cortex / physiology
  • Prefrontal Cortex / physiopathology
  • Receptors, Dopamine D2 / analysis
  • Receptors, Dopamine D2 / drug effects
  • Receptors, Dopamine D2 / physiology*
  • Salicylamides
  • Tomography, Emission-Computed / statistics & numerical data


  • Fluorine Radioisotopes
  • Receptors, Dopamine D2
  • Salicylamides
  • desmethoxyfallypride
  • Ethanol