The complete genomic sequence of Nocardia farcinica IFM 10152

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14925-30. doi: 10.1073/pnas.0406410101. Epub 2004 Oct 4.


We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Chromosome Mapping
  • Chromosomes, Bacterial / genetics
  • Genome, Bacterial*
  • Molecular Sequence Data
  • Nocardia / genetics*
  • RNA Polymerase II / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • RNA Polymerase II

Associated data

  • GENBANK/AP006618
  • GENBANK/AP006619
  • GENBANK/AP006620