Geographical variations in heart deaths and diabetes: effect of climate and a possible relationship to magnesium

J Am Coll Nutr. 2004 Oct;23(5):521S-524S. doi: 10.1080/07315724.2004.10719394.


Background: Geographical variations in deaths from heart disease and the prevalence of diabetes occur in the United States.

Methods: These geographical variations, by state, were compared to the tertiles of the Z-score (Z-climate) obtained from the mean annual temperature and precipitation, by state, and to the tertiles of the Z-score (Z-environment) obtained from six environmental factors, by state, in monovariant analyses of variance.

Results: Both Z-scores were significantly related to male heart deaths (Z-climate: p = 0.000009; Z-environment: p = 0.000043) with Z-climate being the most significant. Both Z-scores were significantly related to the 1998 prevalence of diabetes (Z-climate: p = 0.00018; Z-environment: p = 0.0059) with the climate again being the most significant.

Conclusions: Increased temperature can increase magnesium sweat losses, which may not be compensated by diet or water intake. Climate relationships to these diseases need further investigation.

MeSH terms

  • Adult
  • Analysis of Variance
  • Cardiovascular Diseases / mortality*
  • Climate*
  • Diabetes Mellitus / epidemiology*
  • Female
  • Geography
  • Humans
  • Magnesium / administration & dosage
  • Magnesium / metabolism*
  • Male
  • Mortality / trends*
  • Prevalence
  • Seasons
  • Sex Factors
  • Sweat / chemistry*
  • Temperature
  • United States / epidemiology


  • Magnesium