Effects of an alleged myostatin-binding supplement and heavy resistance training on serum myostatin, muscle strength and mass, and body composition

Int J Sport Nutr Exerc Metab. 2004 Aug;14(4):461-72. doi: 10.1123/ijsnem.14.4.461.


This study examined 12 wk of resistance training and cystoseira canariensis supplementation on serum levels of myostatin and follistatin-like related gene (FLRG) and muscle strength and body composition. Twenty-two untrained males were randomly assigned to a placebo (PLC) or myostatin binder (MYO) group in a double-blind fashion. Blood was obtained before and after 6 and 12 wk of training. PLC and MYO trained thrice weekly using 3 sets of 6 to 8 repetitions at 85 % to 90 % 1 repetition maximum. MYO ingested 1200 mg/d of cystoseira canariensis. Data were analyzed with 2-way ANOVA. After training, total body mass, fat-free mass, muscle strength, thigh volume/mass, and serum myostatin and FLRG increased for both groups (P < 0.05); however, there were no differences between groups (P > 0.05). Twelve wk of heavy resistance training and 1200 mg/d of cystoseira canariensis supplementation appears ineffective at inhibiting serum myostatin and increasing muscle strength and mass or decreasing fat mass.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Anthropometry
  • Body Composition / drug effects*
  • Body Composition / physiology
  • Dietary Supplements*
  • Double-Blind Method
  • Follistatin-Related Proteins / blood
  • Follistatin-Related Proteins / metabolism
  • Humans
  • Male
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / physiology
  • Myostatin
  • Phaeophyta*
  • Time Factors
  • Transforming Growth Factor beta / antagonists & inhibitors
  • Transforming Growth Factor beta / blood*
  • Transforming Growth Factor beta / metabolism
  • Weight Lifting / physiology*


  • Follistatin-Related Proteins
  • MSTN protein, human
  • Myostatin
  • Transforming Growth Factor beta