The significance of using pooled human serum in human articular cartilage tissue engineering

Med J Malaysia. 2004 May;59 Suppl B:13-4.


Animal serum is commonly used in chondrocytes culture expansion to promote cell proliferation and shorten the time lag before new tissue reconstruction is possible. However, animal serum is not suitable for regeneration of clinical tissue because it has potential risk of viral and prion related disease transmission particularly mad cow disease and foreign protein contamination that can stimulate immune reaction leading to graft rejection. In this context, human serum as homologous supplement has a greater potential as growth promoting agents for human chondrocytes culture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Donors
  • Cartilage, Articular / growth & development
  • Cartilage, Articular / transplantation*
  • Cell Count
  • Cell Division / physiology
  • Child
  • Chondrocytes / cytology*
  • Culture Media
  • Female
  • Humans
  • Male
  • Middle Aged
  • Serum*
  • Tissue Engineering*


  • Culture Media