Biocompatibility test of polyhydroxybutyrate on human cell line

Med J Malaysia. 2004 May:59 Suppl B:101-2.


The human fibroblast MRC-5 cells incubated with PHB granules (TM) added at a final concentration of 4 mg/ml showed a time-course pattern of survival. The percentages of dead cells obtained were at the rate of 3.8% after 7 days, respectively. When the MRC-5 cells grown in different material, using the test concentration of 4 mg/ml PCM, they were found to show a similar time-course increasing pattern of death as that obtained with PHB. However, the death was noted in the cells incubated for 7 days, the death rates obtained was 40.54% respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Survival / drug effects*
  • Fibroblasts / drug effects
  • Humans
  • Hydroxybutyrates / toxicity*
  • In Vitro Techniques
  • Materials Testing*
  • Polymers / toxicity*
  • Prohibitins


  • Hydroxybutyrates
  • PHB protein, human
  • Polymers
  • Prohibitins