Locally produced bovine bone sponge as a haemostatic agent

Med J Malaysia. 2004 May;59 Suppl B:149-50.


The aim of this study was to evaluate the morphological and biological properties of a locally produced "Bovine Bone Sponge" for use in dentistry. Bovine bone sponge was prepared from local calf bone. Endotoxin level and surface properties were investigated. The pore size and water uptake ability were measured and results were compared with the commercial haemostatic agent. The material was tested for its haemostatic property and its inhibition of alveolar bone resorption in a sheep model following dental extraction. Results revealed a significant difference in haemostatic effect, and a shorter bleeding time and a lower rate of alveolar bone resorption in bovine bone sponge compare to a commercial haemostatic agent.

MeSH terms

  • Alveolar Bone Loss / prevention & control
  • Animals
  • Biocompatible Materials*
  • Bone and Bones*
  • Cattle
  • Endotoxins / analysis
  • Hemorrhage / therapy*
  • Hemostatics*
  • Limulus Test
  • Microscopy, Electron, Scanning
  • Sheep
  • Surgical Sponges*
  • Tooth Extraction*


  • Biocompatible Materials
  • Endotoxins
  • Hemostatics