Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol

Intern Med. 2004 Aug;43(8):737-40. doi: 10.2169/internalmedicine.43.737.


We successfully treated a patient with occupational hypersensitivity pneumonitis (HP) caused by Grifola frondosa (Maitake) mushroom spore with an extra-fine aerosol corticosteroid; beclomethasone dipropionate (BDP) dissolved in hydrofluoroalkane-134a (HFA). A 49-year-old woman developed respiratory symptoms 3 months after beginning work on a mushroom farm. She was diagnosed as HP based on radiological and serological findings. Oral prednisolone therapy improved her HP and she returned to the same farm. Her HP relapsed after 5 months, and daily 400 microg of HFA-BDP was administered with gradual improvement. An extra-fine particle inhaled corticosteroid might reach appropriate alveoli to be effective therapy for mild HP.

Publication types

  • Case Reports

MeSH terms

  • Administration, Inhalation
  • Aerosol Propellants
  • Agaricales / immunology*
  • Agricultural Workers' Diseases / drug therapy*
  • Agricultural Workers' Diseases / immunology*
  • Alveolitis, Extrinsic Allergic / drug therapy*
  • Alveolitis, Extrinsic Allergic / immunology*
  • Beclomethasone / administration & dosage
  • Female
  • Glucocorticoids / administration & dosage
  • Humans
  • Hydrocarbons, Fluorinated / administration & dosage
  • Middle Aged
  • Spores, Fungal / immunology


  • Aerosol Propellants
  • Glucocorticoids
  • Hydrocarbons, Fluorinated
  • Beclomethasone
  • apaflurane