Midazolam sedation reversed with flumazenil for cardioversion

Br J Anaesth. 1992 Mar;68(3):303-5. doi: 10.1093/bja/68.3.303.


Midazolam was used for anaesthesia in 20 patients undergoing cardioversion; 10 received flumazenil, which caused immediate rapid reversal of anaesthesia, and these patients maintained SpO2 greater than 95%, breathing air, within 5-10 min. In contrast, patients in the placebo group were still partially sedated and required oxygen therapy for up to 2 h to maintain a normal SpO2. Arterial pressure, but not heart rate, also was greater in the flumazenil group in the recovery period.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Anesthesia Recovery Period
  • Anesthesia, Intravenous*
  • Arrhythmias, Cardiac / therapy
  • Blood Pressure / drug effects
  • Double-Blind Method
  • Electric Countershock*
  • Flumazenil / pharmacology*
  • Heart Rate / drug effects
  • Humans
  • Midazolam / antagonists & inhibitors*
  • Middle Aged


  • Flumazenil
  • Midazolam